Lauren Weedman made her television debut on Comedy Central's Emmy Award-winning THE DAILY SHOW WITH JON STEWART in 2001 as a featured Correspondent. It was at that same time that Lauren was a regular on NPR's national political satire show REWIND, and appeared in her solo show HOMECOMING, Off-Broadway at the Westside Theatre. The New York Times said of Lauren and HOMECOMING, “Like Bob Newhart in his early stand-up routines, she's particularly good at making her points – and making us feel clever. Most important, she's just plain funny, physically and verbally.”  For two years, Lauren was also a cast member for the long-running local-turned-national comedy show ALMOST LIVE for Comedy Central.

After studying, writing and performing in Amsterdam for five years, Lauren returned to the States with a bang. Her first play HOMECOMING began as a 15-minute performance art piece that grew into a full-length show, and ultimately toured with the Seattle Repertory Theatre.  

Later that year, HOMECOMING was featured at HBO's U.S. Comedy Arts Festival in Aspen, Colorado, and later found its way to New York City.   HOMECOMING earned Lauren the honor of being published in Women Playwrights: The Best Plays of 2002 .

In the fall of 2002, The Empty Space Theatre in Seattle premiered her solo work RASH, directed by Trip Cullman with music by David Russell and produced by Arielle Tepper Productions.